Under the PMTA process, manufacturers must submit comprehensive scientific data demonstrating that their product is suitable for public health protection. This includes evidence on product composition, manufacturing processes, health risks, and the likelihood of use by non-tobacco users, particularly youth.

Minimum Age Requirement: As of December 20, 2019, the federal minimum legal age to purchase tobacco products, including e-cigarettes, is 21

The Prevent All Cigarette Trafficking (PACT) Act prohibits the use of the U.S. Postal Service for shipping e-cigarettes and vaping products, aiming to curb youth access through online sales .​